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本文就艮他霉素和N-亚胺硫霉素(以下称MK0787)在pH7.4和pH7.0时对绿脓杆菌的抗菌活性进行了比较,为合理选择氨基糖苷类抗生素提供了实验室证据。MK0787是对绿脓杆菌具有强大抗菌活性的新的β-内酰胺抗生素,无论细菌接种量的改变以及培养基pH的变化都不影响其抗菌活性;而艮他霉素的活性则随着pH的降低而减弱。pH7.4和接种菌量为5×10~5cfu/ml时艮他霉素对于绿脓杆菌的活性略优于MK0787,其最低抑菌浓度(MIC)为0.9mg/l,最低杀菌浓度(MBC)为2.1mg/l;后者的MIC为
In this paper, the antibacterial activity of gentamicin and gentamycin (hereinafter referred to as MK0787) at pH7.4 and pH7.0 were compared to provide a laboratory for the rational selection of aminoglycoside antibiotics evidence. MK0787 is a new β-lactam antibiotic which has strong antibacterial activity against Pseudomonas aeruginosa. The change of bacterial inoculation amount and the change of medium pH do not affect the antibacterial activity. However, the activity of gentamicin increases with the increase of pH Reduce and reduce. The results showed that gentamycin had a slightly better activity against Pseudomonas aeruginosa than that of MK0787 at pH7.4 and inoculum size of 5 × 10 ~ 5 cfu / ml with a MIC of 0.9 mg / l and a minimum bactericidal concentration (MBC ) Is 2.1mg / l; the MIC of the latter