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实验证实去基质血红蛋白液(SFH)在无红细胞存在时可维持灵长目类生命,但SFH内血红蛋白(Hb)含量过低则引起一系列生理及血流动力学改变,若增加SFH中Hb,又可使胶渗压(COP)增高(>60 torr)。本文作者研制出一种聚合吡哆酸化Hb液(Poly SFH-P),可弥补SFH之不足。本文旨在证明Poly SFH-P在无红细胞参与下维持血流动力学及氧输送的能力。 6只狒狒麻醉后,气管内插管辅助呼吸,调整呼吸频率及潮气量,使PaCO_2维持在35～45
Experiments confirmed that stromal hemoglobin fluid (SFH) in the absence of red blood cells can maintain the primacy of life, but the SFH hemoglobin (Hb) content is too low is caused by a series of physiological and hemodynamic changes, if increased SFH Hb, but also The plastic osmotic pressure (COP) increased (> 60 torr). The author of the paper developed a polymeric pyridoxing Hb solution (Poly SFH-P), which can make up for the lack of SFH. This article aims to demonstrate the ability of Poly SFH-P to maintain hemodynamics and oxygen delivery without erythroid involvement. Six baboons anesthetized, endotracheal intubation assisted breathing, adjusting respiratory rate and tidal volume, PaCO_2 maintained at 35 ~ 45