摘要目的探讨基于不同时间点DWI和增强MRI参数对乳腺癌新辅助化疗的预测价值。方法纳入经伦理委员会批准并签署书面知情同意的42例乳腺癌病人。研究病人在使用新辅助化疗前以及使用新辅助化疗中3个不同时间点CE-MRI上肿瘤的直径和容积、2D和分段3D兴趣区测量的ADC值。使用受试者操作特征曲线下面积(AUC)来预测病理完全缓解(pCR)。结果病理完全缓解(pCR)和非病理完全缓 Abstract Objective To investigate the predictive value of neoadjuvant chemotherapy for breast cancer based on DWI and MRI parameters at different time points. METHODS: Forty-two breast cancer patients, who were approved by the Ethics Committee and signed a written informed consent. The diameter and volume of tumors on CE-MRI and the ADC values ​​measured in 2D and segmented 3D regions of interest were studied before neoadjuvant chemotherapy and at 3 different time points with neoadjuvant chemotherapy. The area under the receiver operating characteristic curve (AUC) was used to predict pathologic complete remission (pCR). Results Complete pathology (pCR) and non-pathological complete slow