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目的:探讨血小板聚集能力及阿司匹林抵抗在合并2型糖尿病的脑梗死患者中发挥的作用。方法:对105例合并2型糖尿病脑梗死患者及116例未合并糖尿病脑梗死患者服用7 d阿司匹林后血小板聚集率及生化等方面的检测,评价阿司匹林抵抗的发生率。结果:合并2型糖尿病脑梗死患者的阿司匹林抵抗高于未合并组,差异有统计学意义(P<0.05)。结论:合并2型糖尿病脑梗死患者阿司匹林抵抗发生率明显增高,临床工作中积极监测血小板聚集率、防治阿司匹林抵抗对脑梗死的治疗有重要意义。
Objective: To investigate the role of platelet aggregation and aspirin resistance in patients with cerebral infarction complicated by type 2 diabetes mellitus. Methods: The incidence of aspirin resistance was evaluated in 105 patients with type 2 diabetes mellitus and 116 patients without diabetes mellitus after taking aspirin for 7 days. Results: The aspirin resistance in patients with type 2 diabetes mellitus was significantly higher than that in patients without cerebral infarction (P <0.05). Conclusion: The incidence of aspirin resistance in patients with type 2 diabetes mellitus is significantly increased. In clinical work, it is important to actively monitor the platelet aggregation rate and prevent aspirin resistance in the treatment of cerebral infarction.