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目的观察20例职业性黑变病的临床表现,探索治疗方法及疗效。方法所有病例均住院收集临床资料,采用大剂量维生素C和还原型谷胱甘肽配合中药按疗程系统治疗。结果本组病例主要接触煤焦油、石油及其分馏产品,接触数年至数十年而发病;经3~4个疗程治疗,色素沉着明显减轻,颜色变浅,皮肤轻度白嫩;其中6例3个疗程后色素斑消退30%~40%,14例4个疗程后色素斑消退50%;通过2~3个月治疗,所有病例均取得好转的疗效;大部分病人均需治疗2~3年皮肤色素才能基本全部消退,13例达到显效或治愈的目的。结论通过系统的3~4个疗程治疗,大部分色素斑可消退,说明维生素C和还原型谷胱甘肽配合中药治疗可达到色素消退的目的。
Objective To observe the clinical manifestations of 20 cases of occupational melanosis and to explore the treatment and efficacy. Methods All patients were hospitalized to collect clinical data, the use of high-dose vitamin C and reduced glutathione with traditional Chinese medicine treatment by treatment system. Results The patients were mainly exposed to coal tar, oil and fractionation products for several years to decades. After 3 to 4 courses of treatment, the pigmentation was significantly reduced, the color was lighter and the skin was mild and tender. Six cases After three courses of pigmentation subsided by 30% to 40%, 14 cases after 4 courses of pigmentation subsided by 50%; through 2 to 3 months of treatment, all cases have achieved a turnaround effect; most patients require treatment of 2 to 3 The skin pigment can basically all subsided, 13 cases achieved markedly or cured purpose. Conclusions Through the systematic treatment of 3 to 4 courses, most of the pigmentation spots subsided, indicating that vitamin C and reduced glutathione combined with traditional Chinese medicine treatment can achieve the purpose of pigment subsidence.