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目的探讨婴幼儿下呼吸道感染继发腹泻患儿血锌含量及锌缺乏发生率,为防治提供参考。方法选择2009年11月至2012年10月儿科住院的≤3岁下呼吸道感染患儿197例(呼吸道感染“腹泻组”44例,呼吸道感染“无腹泻组”153例);另选同期门诊健康体检的348名婴幼儿为健康“对照组”。空腹采集静脉血2mL,测定锌含量,对结果分组比较分析。结果 “对照组”、“腹泻组”和“无腹泻组”患儿血锌值(μmol/L)分别为(19.51±4.67)、(15.47±4.98)和(14.94±6.34),锌缺乏发生率分别为0.6%、13.6%和19.0%;“腹泻组”、“无腹泻组”患儿血锌含量均比“对照组”低;腹泻组“与”无腹泻组“间血锌含量差异无统计学意义;”腹泻组“与”无腹泻组“患儿缺锌发生率均高于”对照组“;而”腹泻组“与”无腹泻组“间锌缺乏的发生率类似。结论婴幼儿下呼吸道感染时应常规检测血锌,指导临床合理补锌,改善患儿锌营养状况,提高治疗效果。
Objective To investigate the incidence of zinc deficiency in children with secondary diarrhea due to lower respiratory tract infection in infants and young children and provide reference for prevention and treatment. Methods A total of 197 pediatric patients with lower respiratory tract infection ≤3 years were enrolled in the pediatric department from November 2009 to October 2012. Among them, there were 44 cases of respiratory infection and diarrhea group and 153 cases of respiratory infection and no diarrhea group. 348 infants and toddlers who selected the same period outpatient physical examination were healthy ”control group“. Fasting blood samples were collected 2mL, the determination of zinc content, the results of comparative analysis. Results The blood zinc levels in control group, diarrhea group and non-diarrhea group were (19.51 ± 4.67), (15.47 ± 4.98) and (14.94 ± 6.34) μmol / ), And the incidence of zinc deficiency were 0.6%, 13.6% and 19.0%, respectively; the blood zinc levels were lower in children with diarrhea group and without diarrhea group than in control group, There was no significant difference in the content of zinc in the blood between the ”diarrhea group“ and ”diarrhea group without diarrhea“. The incidence of zinc deficiency was higher in the diarrhea group than in the control group The incidence of zinc deficiency in ”diarrhea group“ and ”diarrhea free group" was similar.Conclusion Zinc should be routinely detected in lower respiratory tract infection in infants and young children, guiding clinical zinc supplementation, improving zinc nutrition status and improving treatment effect .