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目的:制备心肌缺血的大鼠病症结合模型,为中医药治疗心肌缺血奠定基础。方法:结合异丙肾上腺素和冰水浴刺激,观察模型大鼠的体征和心肌病理变化。结果使模型大鼠出现皮毛蓬松、竖立无光泽、小便色清、大便湿烂、耳廓唇周暗红、耳廓肿大、爪尾部紫暗等体征,心肌病理明显表现出缺血样坏死。结论:该方法可制备出基本符合的大鼠心肌缺血的病症结合模型。
OBJECTIVE: To establish a rat model of myocardial ischemia combining with Chinese medicine for the treatment of myocardial ischemia. Methods: Combined with isoproterenol and ice water bath stimulation, the signs and pathological changes of the model rats were observed. The results showed that the model rats appeared fluffy fur, erected matte, urine color, stool wet, dark red lips, ear enlargement, dark purple tail and other signs, myocardial pathology showed ischemic necrosis. Conclusion: This method can be used to prepare a consistent model of myocardial ischemia combined with the disease.