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1 miR-210简述MicroRNA(miRNA)是一类生物体内自然生成的长度约21~23 nt的单链非编码小RNA。1993年Ambros等在研究线虫体内发现了第1个miRNA,即line-4参与调节线虫的幼虫发育进程[1]。2007年报道了miRNA的表达受到缺氧的影响,而且在缺氧的正常或者肿瘤细胞中miR-210是目前众多miRNA中公认的表达水平最稳定且显著的miRNA之一。近年来研究发现,miR-210与缺血性脑卒中密切
1 Introduction to miR-210 MicroRNAs (miRNAs) are naturally occurring single-stranded, non-coding small RNAs of approximately 21 to 23 nt in length in organisms. In 1993, Ambros et al. Found the first miRNA in the study of nematode, that is, line-4 is involved in the regulation of nematode larval development [1]. In 2007, miRNA expression was reported to be affected by hypoxia, and miR-210 is one of the most stable and significant miRNAs recognized by many miRNAs in hypoxic normal or tumor cells. Recent studies have found that miR-210 is associated with ischemic stroke