增生性玻璃体视网膜病变(PVR)是由多种细胞因子参与的眼底疾病，其重要的病理过程是视网膜色素上皮(RPE)细胞的上皮－间充质转化(EMT)。肿瘤坏死因子(TNF)是一种重要的炎性反应诱导因子，可由活化的RPE细胞、小胶质细胞、单核细胞和巨噬细胞产生，进而参与PVR发生和发展过程。除了细胞因子之外，表观遗传学因素如DNA甲基化也在PVR的发生中起了重要作用，其中甲基CpG结合蛋白(MeCP2)参与EMT及纤维化，且在PVR膜中有较高的表达，转化的RPE细胞和小胶质细胞也存在MeCP2的阳性表达，推测MeCP2在PVR发生和发展过程中具有重要作用。TNF也可刺激MeCP2的表达。因此，本文就MeCP2在PVR形成中的作用以及TNF与MeCP2之间的交互反应在PVR形成中的作用进行综述。“,”Proliferative vitreoretinopathy (PVR) is an ocular fundus disease involving multiple cytokines.Its important pathological process is epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells.Tumor necrosis factor (TNF) is an important inflammatory response inducing factor, which can be produced by activated RPE cells, microglia, monocytes and macrophages, and then participate in the occurrence and development of PVR.In addition to cytokines, epigenetic factors such as DNA methylation also play an important role in the development of PVR, in which methyl-CpG binding protein 2(MeCP2) is involved in EMT and fibrosis, and is highly expressed in PVR membrane.The positive expression of MeCP2 is also found in transformed RPE cells and microglia.It is speculated that MeCP2 plays an important role in the occurrence and development of PVR.TNF can also stimulate the expression of MeCP2.This article reviews the role of MeCP2 and the interaction between TNF and MeCP2 in the formation of PVR.