目的　探讨安徽省不同地区钩端螺旋体病的特征。方法　采用病原学和血清学对自然人群感染情况及主要宿主感染情况及带菌率、菌群分布进行调查。结果　不同地理区划人群感染率及流行菌群均不相同 ,皖南山区出现菌型更迭现象。结论　淮河长江流域自然人群隐性感染率下降 ,宿主动物均有带菌 ,疫区仍然存在 ;皖南山区与七十年代持平 ,并发现新的菌型 ,是九十年代重点疫区 ,应采取相应防治措施 Objective To explore the characteristics of leptospirosis in different areas of Anhui Province. Methods The etiology and serology were used to investigate the infection status of main population, the infection rate of main host, the carrying rate and the flora distribution in the natural population. Results The rates of infection and prevalence in different geographical divisions were all different, and the phenomenon of bacteria was changed in mountainous areas of southern Anhui. Conclusions The latent infection rate of natural populations in the Huaihe River Valley decreased. All the host animals were infected with the disease, and the epidemic area still existed. The mountainous area in southern Anhui was the same as the seventies, and the new bacterial type was found. It was the key epidemic area in the 1990s. Measures