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来乐司酮是抗孕激素催经止孕药RU_(486)的类似物,其特点是动物实验的抗早孕作用比RU_(486)强,但抗糖皮质激毒活性却比后者低,是一个有希望成为RU_(486)的换代药。Ames、染色体畸变及小鼠骨髓多染红细胞微核计数等三项致突变试验结果表明,来乐司酮均为阴性。
It is an analogue of RU_ (486), a progestational antigestin, that has been shown to be more effective than RU 486 in animal experiments but less active in anti-glucocorticoid activity, A promising replacement for RU_ (486). Ames, chromosomal aberrations and mouse bone marrow erythrocytes micronucleus count three mutagenic test results show that to the majority of toxaprine were negative.