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双—三氯甲基砜是人工合成的杀菌剂。双—三氯甲基砜以30mg/kg剂量每天1次每周6次连续4周给大鼠用药可使雄性大鼠丧失生育力,但交配行为及健康状况均正常。为研究该药所致不育的可逆性,对连续4周用药(每天30mg/kg)的雄性大鼠继续用药4周,保持不育状态。然后停药4周,见生育力开始恢复,又过2周后生育力恢复至对照水平。各项观测,包括睾丸组织学、附睾精子活力和密度,血清睾酮、附性腺重量及重要器官组织学观察的结果均与对照无显著差异。结果表明在所用剂量下,双—三氯甲基砜引起的不育是完全可逆的。
Bis-trichloromethyl sulfone is a synthetic fungicide. Bis-trichloromethylsulfone at 30mg / kg once a day for 6 times a week for 4 consecutive weeks to rats in rats can lose male rats fertility, but the mating behavior and health are normal. In order to study the reversibility of infertility induced by this drug, male rats that were treated for 4 consecutive weeks (30 mg / kg / day) were continued for 4 weeks to maintain their sterility. Then stop for 4 weeks, see fertility began to recover, and after 2 weeks fertility restored to the control level. Various observations, including testicular histology, epididymal sperm motility and density, serum testosterone, gonadal weight and vital organ histological observations were no significant differences with the control. The results show that steroid induced by bis-trichloromethylsulfone is completely reversible at the doses used.