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目的探讨急性脑梗死(ACI)患者同型半胱氨酸(Hcy)与高敏C反应蛋白(hs-CRP)及凝血及纤溶功能的关系。方法选择100例ACI患者(ACI组)并以80例非脑梗死患者为对照(NC组),检测并比较其血浆Hcy、hs-CRP、国际标准化比值(INR)、活化部分凝血活酶时间(APTT)、血浆组织型纤溶酶原激活物(rt-PA)及血浆纤溶酶原激活抑制物-1(PAI-1)。结果 ACI组血浆Hcy、hs-CRP、rt-PA、PAI-1水平比NC组增高,而INR和APTT时间则较NC组缩短,差异有统计学意义(P<0.05)。ACI组血浆Hcy水平与hs-CRP、PAI-1水平呈正相关。结论 ACI患者血浆Hcy水平与hs-CRP、凝血、纤溶功能水平的改变有关。
Objective To investigate the relationship between homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP) and coagulation and fibrinolysis in patients with acute cerebral infarction (ACI). Methods 100 ACI patients (ACI group) and 80 non-cerebral infarction patients (NC group) were enrolled in this study. The plasma Hcy, hs-CRP, INR, and partial thromboplastin time APTT), plasma tissue plasminogen activator (rt-PA) and plasma plasminogen activator inhibitor-1 (PAI-1). Results The plasma levels of Hcy, hs-CRP, rt-PA and PAI-1 in ACI group were higher than those in NC group, while the INR and APTT time were shorter than NC group (P <0.05). Plasma Hcy levels in ACI group were positively correlated with hs-CRP and PAI-1 levels. Conclusion The plasma Hcy level in ACI patients is related to the changes of hs-CRP, coagulation and fibrinolysis.