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目的 研究新生儿红细胞增多症 (PCM )血液流变学的变化及其与器官损害的关系。方法 分析 34例PCM与 15例单纯新生儿高胆红素血症 (高胆组 )的血液流变学 7项指标的变化 ,并观察PCM中合并脑损害和心肌损害患儿的血液流变学变化。结果 PCM低切变全血粘度、红细胞的凝集性均较单纯高胆组明显升高 (P <0 0 1) ;PCM病例中病因为宫内慢性缺氧者与围产期胎盘过多输血者比较 ,前者低切变全血粘度明显比后者高 (P<0 0 5 ) ,而红细胞变形性前者明显比后者低 (P <0 0 5 ) ;合并器官损害的PCM病例全血粘度、红细胞凝集性明显较未合并损害者高 (P <0 0 5 ,P <0 0 1) ,而变形性明显降低 (P <0 0 1)。结论 PCM患儿全血粘度升高 ,且随病因不同而不同 ,治疗时应首先改善红细胞的凝集性和变形性 ,以减轻对器官的损害
Objective To study the changes of hemorheology in neonates with polycystic ovary (PCM) and its relationship with organ damage. Methods The changes of hemorheology in 34 cases of PCM and 15 cases of pure neonatal hyperbilirubinemia (hypercholesterolemia) were analyzed. The hemorheology of PCM in children with brain damage and myocardial damage Variety. Results The low shear viscosity of whole blood and the agglutination of erythrocytes in PCM were significantly higher than that in pure hypercholesterolemia group (P <0.01). The causes of PCM in chronic intrauterine hypoxia and perinatal hyperplasia (P <0.05), while the former was significantly lower than the latter (P <0 05). The whole blood viscosity of patients with PCM complicated with organ damage, The agglutination of erythrocyte was significantly higher than that of the uninjured group (P <0.05, P <0.01), while the deformability was significantly lower (P <0.01). Conclusion The whole blood viscosity of children with PCM increased, and with different causes of different treatment should be the first to improve the agglutination and degeneration of red blood cells in order to reduce the damage to the organ