论文部分内容阅读
在我国白内障是造成视力障碍的主要因素。糖尿病性白内障(DC)是糖尿病的慢性并发症之一,其致盲率仅次于糖尿病视网膜病变(DR),糖尿病的发病率逐年上升的同时,DC的发病率也在增加。虽然白内障手术能够治愈DC,但研究人员仍致力于研究其发病机制以求通过药物途径治疗或预防DC。最近的研究显示,白内障的生成与晶状体内某些成分的改变有直接或间接的关系,DC发病过程中更是有一些特殊的改变:多元醇通路与DC的发展有着紧密的联系,有学者认为多元醇积聚诱发了白内障形成;氧化损伤在白内障形成过程中起了重要作用,而高血糖使得晶状体中多种抗氧化酶受损;晶状体本身是人体蛋白质含量最高的器官,白内障本质上即为结构蛋白的变性,而某些晶状体蛋白作为结构蛋白的同时又具有功能性蛋白的特性,其性质的改变引发晶状体混浊。本文针对DC相关的某些晶状体蛋白及酶类的研究进展做一综述。
Cataracts in our country are the main causes of visual impairment. Diabetic cataract (DC) is one of the chronic complications of diabetes, its blindness rate is second only to diabetic retinopathy (DR). The incidence of diabetes mellitus is increasing year by year, while the incidence of DC is also increasing. Although cataract surgery can cure DC, researchers are still working to study its pathogenesis in order to treat or prevent DCs through the drug route. Recent studies have shown that there is a direct or indirect relationship between the formation of cataract and the changes of some components of the lens. There are some special changes in the pathogenesis of DC: the development of polyvalent alcohol channels and DC are closely linked, some scholars think Polyatomic accumulation induces cataract formation; oxidative damage plays an important role in the formation of cataracts, and hyperglycemia impairs multiple antioxidants in the lens; the lens itself is the organ with the highest protein content in the human body, and cataracts are essentially structures Protein denaturation, and some lens proteins as structural proteins also have the characteristics of a functional protein, the changes in the nature of the cause lens opacity. This article reviews some of the research progress on DC-related crystalline proteins and enzymes.