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目的:探讨不同糖耐量状态下绝经后女性血清氧化低密度脂蛋白(ox-LDL)水平及其相关影响因素。方法:选取120例绝经后女性,其中糖耐量正常(NGT组)40例、糖耐量受损(IGR组)40例及2型糖尿病(T2DM组)40例。采用ELISA检测血清中ox-LDL水平,分析比较各组ox-LDL的水平及其与血脂、血糖(FBG)、收缩压(SBP),舒张压(DBP)、同型半胱氨酸(Hcy)的相关性。结果:与NGT组比,T2DM组及IGR组均具有较高的ox-LDL、LDL-C、SBP、DBP水平(P<0.05),且T2DM组血Hcy明显高于NGT组(P<0.01)。与IGR组相比,T2DM组具有较高的ox-LDL、TG、TCH、LDL-C、FBG及低HDL-C水平(P<0.05),两组间的SBP、DBP、Hcy差异无统计学意义(P>0.05)。多元线性回归分析ox-LDL与Hcy、LDL-C、FBG、SBP呈正相关,与HDL-C呈负相关(P<0.05),各相关指标对ox-LDL水平影响的标准化回归系数(β)分别为0.394(FBG)、0.213(Hcy)、0.177(SBP)、-0.139(HDL-C)和0.125(LDL-C)(P<0.05)。结论:随着糖耐量异常程度的加重,血清ox-LDL水平也呈升高趋势,而且高血糖、高Hcy、高血压及血脂紊乱是ox-LDL的独立危险因素。
Objective: To investigate the serum levels of oxidized low density lipoprotein (ox-LDL) and its related factors in postmenopausal women with different glucose tolerance status. Methods: A total of 120 postmenopausal women were selected. Among them, 40 were normal glucose tolerance (NGT group), 40 were impaired glucose tolerance (IGR group), and 40 were type 2 diabetes mellitus (T2DM group). The levels of ox-LDL in serum were detected by ELISA. The level of ox-LDL in each group was compared with that of blood glucose, blood glucose (FBG), SBP, DBP and homocysteine Correlation. Results Compared with NGT group, the levels of ox-LDL, LDL-C, SBP and DBP in T2DM group and IGR group were significantly higher than those in NGT group (P <0.05) . Compared with IGR group, T2DM group had higher levels of ox-LDL, TG, TCH, LDL-C, FBG and low HDL-C (P <0.05) Significance (P> 0.05). Multivariate linear regression analysis showed that ox-LDL was positively correlated with Hcy, LDL-C, FBG and SBP, and negatively correlated with HDL-C (P <0.05). The standardized regression coefficients Were 0.394 (FBG), 0.213 (Hcy), 0.177 (SBP), -0.1339 (HDL-C) and 0.125 (LDL-C) (P <0.05). CONCLUSIONS: With the aggravation of glucose tolerance abnormalities, serum ox-LDL level also tends to increase. And hyperglycemia, hypercytosis, hypertension and dyslipidemia are independent risk factors of ox-LDL.