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目的:探讨RHR脑梗死后病灶边缘额、顶叶皮层脑组织突触体内[Ca~(2+)]_i水平及其对神经生长因子(NGF)治疗的变化。方法:用Fura-2荧光标记,测定分离突触体内[Ca~(2+)]_i。结果:在RHR脑梗死后,静息状态下病灶边缘额、顶叶皮层脑组织突触体内[Ca~(2+)]_i在第3、7及14d明显升高,NGF脑室内注射12d后明显降低,同时减少运动障碍评分。结论:病灶边缘皮层突触体内[Ca~(2+)]_i的升高不利于神经运动功能的恢复,NGF降低突触体内[Ca~(2+)]_i促进运动功能恢复。
Objective: To investigate the changes of [Ca ~ (2 +)] _i and the treatment of nerve growth factor (NGF) in brain frontal cortex and parietal cortex after RHR infarction. Methods: Fura-2 fluorescent labeling was used to detect [Ca ~ (2 +)] _i in synaptosomes. Results: After the cerebral infarction of RHR, [Ca ~ (2 +)] _ i in the frontal cortex and parietal cortex of the parietal cortex were significantly increased at rest on the 3rd, 7th and 14th days after intravenous injection of NGF for 12 days Significantly reduced, while reducing dyskinetic score. Conclusion: The increase of [Ca ~ (2 +)] _ i in the marginal cortical synaptosome is not conducive to the restoration of motor function. NGF can decrease the [Ca ~ (2 +)] _ i in synaptosome and promote the recovery of motor function.