原发性高血压常需频繁给药及联合用药,因而使得病人难于坚持治疗。Ram等报告12例轻至中度高血压病人,用可乐宁—氯噻酮每日一次睡前服或每日2次给药,控制血压的效果没有区别。笔者为比较Combipres(可乐宁与氯噻嗪的固定混合药片)每日一次及每日2次的效果,用公斤标记(Open-label),交叉设计研究 Essential hypertension often require frequent administration and combination therapy, thus making it difficult for patients to adhere to the treatment. Ram and other reports of 12 cases of mild to moderate hypertensive patients with clonidine - chlorthalidone daily bedtime or twice daily dosing, the effect of controlling blood pressure there is no difference. In order to compare the effects of Combipres (twice daily and twice daily) with Combipres (fixed mixed tablets of clonidine and chlorothiazide), we used open-label, cross-over design studies