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目的探讨四磨汤联合小剂量阿普唑仑治疗便秘型肠易激综合征的临床疗效。方法选取90例便秘型肠易激综合征患者,按照前来就诊的序号将90例便秘型肠易激综合征患者随机分为两组,单号为研究组(45例),双号为对照组(45例)。对照组给予临床常规西医药物治疗;研究组在常规西医治疗基础上加用四磨汤,记录两组患者持续治疗2个月后所得临床疗效及相关不良反应发生情况,经分析后得出结论。结果研究组临床治疗总有效率(93.33%)显著高于对照组(73.33%),差异有统计学意义(P<0.05);研究组不良反应发生率为17.78%,对照组不良反应发生率为13.33%,差异未见统计学意义(P>0.05)。结论便秘型肠易激综合征患者经四磨汤联合小剂量阿普唑仑联合治疗后可获得满意疗效及安全性,有利于保障患者生活质量。
Objective To investigate the clinical effect of Si mill soup combined with low dose alprazolam in the treatment of constipation-type irritable bowel syndrome. Methods Ninety patients with constipation-type irritable bowel syndrome were selected and randomly divided into two groups (n = 45) according to the serial number of the attending physician. The double number was control Group (45 cases). The control group was given routine western medicine treatment. The study group added four mill soup on the basis of routine western medicine treatment. The clinical efficacy and adverse reactions of the two groups were recorded after two months’ continuous treatment. The conclusion was obtained after analysis. Results The total clinical effective rate (93.33%) in the study group was significantly higher than that in the control group (73.33%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the study group was 17.78%. The incidence of adverse reactions in the control group was 13.33%, the difference was not statistically significant (P> 0.05). Conclusions The patients with constipation-type irritable bowel syndrome can get satisfactory curative effect and safety after combination of Si-ming decoction and low-dose alprazolam, which helps to ensure the quality of life of patients.