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目的:观察注射用丹参多酚酸盐联合西药治疗冠心病不稳定性心绞痛的临床疗效。方法:选取54例冠心病不稳定性心绞痛患者为研究对象,按照随机数字表法分为治疗组和对照组各27例。对照组给予西药治疗,治疗组在对照组用药基础上联合注射用丹参多酚酸盐治疗。比较2组心绞痛、心电图疗效及不良反应发生率,观察2组治疗前后的血液流变学指标(红细胞聚集指数、血浆黏度)和血小板凝聚率的变化。结果:治疗组的心绞痛及心电图疗效总有效率分别为88.89%和85.19%,高于对照组的62.96%和59.26%。2组心绞痛及心电图疗效总有效率比较,差异均有统计学意义(P<0.05)。治疗前,2组血小板凝聚率、血浆黏度及红细胞聚集指数比较,差异均无统计学意义(P>0.05)。治疗后,2组血小板凝聚率、血浆黏度及红细胞聚集指数均较治疗前改善,差异均有统计学意义(P<0.01);治疗组3项指标的改善情况均优于对照组,差异均有统计学意义(P<0.01)。治疗期间2组均无不良反应发生。结论:注射用丹参多酚酸盐联合西药治疗冠心病不稳定性心绞痛,能有效减轻患者的心绞痛程度,促进心电图恢复,改善血液流变学指标和血小板凝聚率。
Objective: To observe the clinical efficacy of salvia miltiorrhiza polyphenols injection combined with western medicine in the treatment of unstable angina pectoris. Methods: Fifty-four patients with unstable angina pectoris were enrolled in this study. According to the random number table, they were divided into treatment group (n = 27) and control group (n = 27). The control group was treated with western medicine, while the treatment group was treated with salvia miltiorrhiza polyphenols in combination with the control group. The incidences of angina pectoris, electrocardiogram (ECG) and adverse reactions were compared between the two groups. The changes of hemorheology index (erythrocyte aggregation index, plasma viscosity) and platelet aggregation rate before and after treatment were observed. Results: The total effective rates of angina pectoris and electrocardiogram in treatment group were 88.89% and 85.19% respectively, which were 62.96% and 59.26% higher than those in control group. The total effective rate of angina pectoris and electrocardiogram in the two groups were statistically significant (P <0.05). Before treatment, there was no significant difference in platelet aggregation rate, plasma viscosity and erythrocyte aggregation index between the two groups (P> 0.05). After treatment, the two groups of platelet aggregation rate, plasma viscosity and erythrocyte aggregation index were improved than before treatment, the difference was statistically significant (P <0.01); treatment group three indicators were better than the control group, the difference was Statistical significance (P <0.01). No adverse reactions occurred in the two groups during the treatment. Conclusion: Injection Salviae miltiorrhizae polyphenols combined with Western medicine in the treatment of unstable angina pectoris can effectively reduce the degree of angina pectoris, promote electrocardiogram recovery and improve hemorrheological indexes and platelet aggregation rate.