论文部分内容阅读
目的探讨溴苯腈急性中毒对小鼠心肌能量代谢的影响及二巯丙磺钠(Na-DMPS)的保护作用。方法 ICR小鼠78只,随机分成5组,对照组、溴苯腈高、低剂量组和Na-DMPS干预组。检测染毒后0.5,3 h心肌腺苷酸含量。结果溴苯腈高剂量组染毒后0.5,3 h,三磷酸腺苷(ATP)含量分别为(39.62±8.39),(41.19±6.56)mg/g,明显低于对照组(49.96±6.87)mg/g(P<0.05);二磷酸腺苷(ADP)含量在染毒后0.5,3 h高于对照组(11.01±0.93)mg/g(P<0.05);磷酸腺苷(AMP)于染毒后3,6 h高于对照组(1.61±0.20)mg/g;Na-MDPS干预后ATP分别为(51.10±7.10),(58.34±12.34),(52.92±14.15)mg/g,明显高于溴苯腈高剂量组(P<0.05);ADP、AMP含量低于溴苯腈高剂量组(P<0.01)。结论溴苯腈急性中毒可影响小鼠心肌能量代谢,Na-DMPS干预可改善心肌能量代谢。
Objective To investigate the effect of bromoxynil acute poisoning on myocardial energy metabolism in mice and the protective effect of sodium dimercaptopropane sulfonate (Na-DMPS). Methods 78 ICR mice were randomly divided into 5 groups: control group, bromoxynil high and low dose groups and Na-DMPS intervention group. The contents of adenosine monophosphate in myocardium were detected at 0.5 and 3 h after exposure. Results The contents of ATP in the bromoxynil high dose group at 0.5, 3 h were (39.62 ± 8.39) and (41.19 ± 6.56) mg / g, respectively, which were significantly lower than those in the control group (49.96 ± 6.87) mg / g (P <0.05). The content of adenosine diphosphate (ADP) was higher than that of the control group (0.51, 0.93) mg / (51.10 ± 7.10), (58.34 ± 12.34) and (52.92 ± 14.15) mg / g, respectively, which were significantly higher than those of the control group (1.61 ± 0.20 mg / (P <0.05). ADP and AMP contents were lower than those of bromoxynil high dose group (P <0.01). Conclusion Acute poisoning of bromoxynil can affect myocardial energy metabolism in mice. Na-DMPS intervention can improve myocardial energy metabolism.