论文部分内容阅读
已知天然的PGE_2及PGF_(2α)有增加平滑肌活动作用,目前,这两种药物已成功地应用于引产。然而天然前列腺素很快即被代谢灭活,为维持其作用,就必须持续给药,同时伴有胃肠活动增加为主的副作用。1971年Bundy等记述了一种改良化学结构的合成前列腺素类似物15(S)-15甲基PGF_(2α),是一种在第15位碳有改变的类似物,可防止被15-脱氢酶快速脱氢,现在认为,15-甲基PGF_(2α)适用于中孕引产。本文目的,是分析早孕期通过静脉给PGF_(2α)及15甲基PGF_(2α)在人体内子宫肌的收缩反应。研究于两组健康妇女中进行,年龄23～42岁,均为早孕要求终止妊娠,进行全面妇科检查,并进行超声检查确定孕期及子宫大小,肌壁厚度,还做宫腔探针测量,子宫收缩反应所依赖的激素环境亦进行测定,试验当日晨行雌二醇及孕酮测定,所有病例的激素值均于相应孕期正常范围内。子宫测量
It is known that natural PGE_2 and PGF_ (2α) increase the activity of smooth muscle. At present, these two drugs have been successfully used in induction of labor. However, natural prostaglandins are quickly metabolically inactivated, in order to maintain its role, we must continue to be administered, accompanied by increased gastrointestinal motility side effects. In 1971, Bundy et al. Described a synthetic prostaglandin analog 15 (S) -15 methyl PGF 2α, which is a modified analogue of carbon at position 15 and protected from 15- Hydrogenase rapid dehydrogenation, now that 15-methyl PGF_ (2α) is suitable for pregnancy induced labor. The aim of this paper is to analyze the contractile responses of PGF 2α and 15-methyl PGF 2α in human uterine muscles during early pregnancy through the veins. The study was conducted in two groups of healthy women aged 23-42 years, both of whom were required to terminate pregnancy in early pregnancy, underwent a comprehensive gynecological examination, and examined by ultrasound to determine gestational age and uterine size, muscle wall thickness, and uterine probe measurements, The hormonal environment on which the contractile response was dependent was also determined. Estradiol and progesterone were measured on the day of the test, and the hormones of all the cases were within the normal range of the corresponding pregnancy. Uterine measurement