整合素连接激酶(ILK)是一种丝氨酸/苏氨酸蛋白激酶,可以同整合素b1、b3亚基胞浆域结合,参与多种信号转导,包括整合素、生长因子及Wnt信号转导通路,在调节细胞黏附、凋亡、转移、生长、细胞周期、肿瘤形成等过程中起重要作用。如果细胞中ILK表达异常,将引发病理变化,其中ILK表达异常与肿瘤转移的关系已引起人们的广泛关注。该文就ILK与肿瘤转移关系研究进展进行综述。 Integrin Ligase (ILK) is a serine / threonine protein kinase that binds to the cytoplasmic domain of integrin b1, b3 subunits and is involved in a variety of signal transduction, including integrins, growth factors, and Wnt signaling Pathway, play an important role in regulating cell adhesion, apoptosis, metastasis, growth, cell cycle, tumor formation and other processes. If abnormal ILK expression in cells, will lead to pathological changes, of which ILK abnormal expression and tumor metastasis has drawn people’s attention. This article reviews the progress of ILK and tumor metastasis.