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目的:探讨口咽部腺样囊性癌(Adenoid cystic carcinoma,ACC)的临床病理特点及鉴别诊断。方法:对8例ACC进行临床病理学观察并复习相关文献。结果:8例ACC的组织学结构上分为筛孔型、管状型、实体型和条索型四种类型。免疫表型:CK(AE1/AE3)阳性,S-100蛋白阳性,肌上皮细胞SMA阳性。结论:口咽部腺样囊性癌局部侵袭性强,早期侵犯神经,复发率高,晚期易出现远处转移。诊断时应注意与多形性腺瘤,基底细胞腺癌,涎腺导管癌相鉴别。治疗手术彻底切除加术后予以放疗可提高患者生存率。
Objective: To investigate the clinicopathological features and differential diagnosis of oro-adenoid cystic carcinoma (ACC). Methods: Eight cases of ACC were observed clinically and pathologically and reviewed the relevant literature. Results: Eight cases of histological structure of ACC divided into mesh, tubular, solid and cords of four types. Immunophenotype: CK (AE1 / AE3) positive, S-100 protein positive, myoepithelial SMA positive. CONCLUSION: Oropharyngeal adenoid cystic carcinoma has strong local invasion, early invasion of nerve, high recurrence rate and distant metastasis in late stage. Diagnosis should be noted with pleomorphic adenoma, basal cell adenocarcinoma, salivary gland ductal carcinoma phase identification. Radical surgical resection plus radiotherapy to improve patient survival after surgery.