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目的:探讨VitA、VitB2辅助硫酸亚铁叶酸片对孕妇贫血的临床疗效及对妊娠结局的影响。方法:常规行孕期检查的260例妊娠期贫血孕妇随机分为FF组(单纯硫酸亚铁叶酸片)、FFA组(硫酸亚铁叶酸片+VitA)、FFB组(硫酸亚铁叶酸片+VitB2)和FFAB组(硫酸亚铁叶酸片+VitA+VitB2组),回顾调查孕妇膳食情况,比较干预前、后血红蛋白(Hb)、血清铁蛋白(SF)、全血谷胱苷肽还原酶活性系数(BGRAC)、VitA含量,随访观察4组孕妇妊娠结局。结果:孕妇Fe、VitA、VitB2摄入量不足,干预治疗8周后4组间Vit A差异无统计学意义(P>0.05),Hb、BGRAC、SF差异有统计学意义(P<0.05)。干预后与干预前比较,FFB组BGRAC降低(P<0.01),FFB组、FFAB组SF均降低(P<0.05);4组的Hb值均有所上升,差异有统计学意义;4组间妊娠不良并发症差异均无统计学意义(P>0.05)。结论:补充VitA对血浆VitA水平正常孕妇无增强补铁改善贫血的效应,补充VitB2可增强补铁治疗贫血的作用,联合应用VitA、VitB2可使铁利用增高,但对血红蛋白改善不存在协同作用。
Objective: To investigate the clinical efficacy of VitA, VitB2-assisted ferrous sulfate folic acid tablets in pregnant women with anemia and its effect on pregnancy outcome. Methods: A total of 260 pregnant women with gestational anemia during routine pregnancy test were randomly divided into FF group (simple ferrous sulfate folic acid tablets), FFA group (ferrous sulfate folic acid tablets + VitA), FFB group (ferrous sulfate folic acid tablets + VitB2) And FFAB group (ferrous sulfate folic acid tablets + VitA + VitB2 group). The diet of pregnant women was retrospectively investigated. The levels of hemoglobin (Hb), serum ferritin (SF) and whole blood glutathione reductase activity BGRAC), VitA levels, follow-up observation of pregnancy outcomes in 4 groups of pregnant women. Results: The intake of Fe, VitA and VitB2 in pregnant women was not enough. There was no significant difference in Vit A between the four groups after 8 weeks of intervention (P> 0.05). The difference of Hb, BGRAC and SF was statistically significant (P <0.05). Compared with pre-intervention, BGRAC in FFB group decreased (P <0.01), SF in FFB group and FFAB group decreased (P <0.05), Hb value in 4 groups increased, with statistical significance There were no significant differences in the complications of poor pregnancy (P> 0.05). Conclusion: Supplementing VitA to normal pregnant women with normal serum VitA level can improve anemia. Supplementing VitB2 can enhance the effect of iron supplementation on anemia. Combined use of VitA and VitB2 can increase iron utilization, but there is no synergistic effect on hemoglobin improvement.