为深入了解血管生成素的生物学作用,探讨其在免疫、造血、血管新生和神经方面可能的生物学功能,我们选择了多种细胞和组织进行实验分析ANG研究。结果表明:其对ECV304和COS7细胞具有促增殖作用,并可观察到明显的促ECV304细胞贴壁的作用;Ang具有明显地促KG-1a增殖的作用,其具体的分子机制有待于进一步的深入研究;Ang对造血干细胞形成集落没有作用,同时发现亦不存在与GM—CSF的协同作用;Ang缺乏直接对鸡胚背根神经节的作用,但可能对胶质细胞的生长有一定的影响。 To gain insight into the biological role of angiogenin and to explore its possible biological functions in immunity, hematopoiesis, angiogenesis and neurogenesis, we selected a variety of cells and tissues for experimental analysis of the ANG study. The results showed that: ECV304 and COS7 cells have a role in promoting proliferation, and can significantly promote the adhesion of ECV304 cells; Ang has a significant role in promoting proliferation of KG-1a, and its specific molecular mechanism needs further in-depth Ang, which had no effect on the formation of colonies by hematopoietic stem cells, also found no synergism with GM-CSF. The lack of direct effect of Ang on the dorsal root ganglion of chick embryo may have an effect on the growth of glial cells.