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目的比较生理盐水和肝素对PICC封管的效果。方法随机选取PICC置管的长期输液患者60例，分为观察组和对照组，每组30例。观察组用20ml生理盐水连续脉冲冲管；对照组采用1u/ml肝素稀释液脉冲冲管。比较两组患者堵管率及血凝指标：凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)。结果两组患者发生堵管均为2例，而观察组患者PT及APTT较对照组明显降低(<0.05)。结论生理盐水脉冲式封管在PICC置管时应用具有方便、性价比高、无风险等优点，值得推广。“,”Objective To compare the normal saline and heparin on PICC sealed tube ef ect.Methods 60 cases were randomly selected patients with long-term infusion of PICC,divided into observation group and control group,30 cases in each group.Observation group with normal saline 20ml continuous pulse red tube;control group using 1u/ml heparin dilution pulse red tube.Comparison of the two groups were blocked tubes rate and blood coagulation indicators:prothrombin time(PT),activated partial thromboplastin time(APTT).Results Tthe two groups of patients with blocked tubes are two cases,while PT and APTT observation group were significantly lower than the control group ( <0.05).Conclusion Saline Pulsed Sealing when PICC catheter with a convenient application,cost-ef ective,risk-free,etc.,should be promoted.