马凡(Marfan)氏综合征是一种先天性普遍性结缔组织异常性疾病。本文结合临床发现的1个家族3例患者报告如下。例1 肖某,男,35岁,工人。因心悸、气短1年,阵发性夜间呼吸困难入院。患者出生后,身躯手脚细长,近视1000度。入学后双脚逐月增长,不能参加激烈活动。22岁结婚,有二子一女,二子 Marfan syndrome is a congenital common connective tissue abnormality. This article combined with clinical findings of a family of 3 patients reported as follows. Example 1 Xiaomou, male, 35 years old, worker. Due to heart palpitations, shortness of breath for 1 year, paroxysmal nocturnal dyspnea admitted to hospital. After the patient is born, the body is slender hands and feet, myopia 1000 degrees. Feet increase month after school, can not participate in intense activities. 22-year-old married, two sons and a daughter, two sons