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目的：研究ＤＨＥ对肠道平滑肌的作用。方法：小鼠、大鼠和豚鼠离体和在体肠道平滑肌上，以吗啡为对照，比较ＤＨＥ与吗啡对肠道平滑肌作用的异同。结果：吗啡和ＤＨＥ减慢小鼠肠推进运动的ＥＤ５０分别为２．７９ｍｇ·ｋｇ－１和３．２３μｇ·ｋｇ－１；ＤＨＥ３６～６０μｇ·ｋｇ－１ｓｃ可松弛小鼠在体肠道平滑肌，在相同的实验条件下，吗啡５～２０ｍｇ·ｋｇ－１ｓｃ可剂量依赖性地收缩小鼠在体肠道平滑肌；在小鼠、大鼠和豚鼠离体肠管上，ＤＨＥ兴奋肠道平滑肌的浓度依次为１０～１００，０．１～１０和１０～１００μｍｏｌ·Ｌ－１，吗啡兴奋肠道平滑肌的浓度分别为０．１～１０，０．００２～２．０和０．１～１０μｍｏｌ·Ｌ－１，而ＤＨＥ兴奋肠道平滑肌的浓度是在镇痛剂量下体内无法达到的。结论：对肠道平滑肌作用，ＤＨＥ与吗啡不同，ＤＨＥ呈舒张效应，而吗啡为收缩效应。
Objective: To study the effect of DHE on intestinal smooth muscle. METHODS: Morphine was used as a control in mice, rats and guinea pigs in vitro and in vivo, comparing the effects of DHE and morphine on intestinal smooth muscle. Results: ED50 of morphine and DHE slowed the intestinal motility of mice was 2.79mg · kg-1 and 3.23μg · kg-1, respectively. DHE 36 ~ 60μg · kg-1sc could relax the intestinal smooth muscle in vivo, Under the same experimental conditions, morphine 5 ~ 20mg · kg-1sc dose-dependently contractible mice in vivo intestinal smooth muscle; in mice, rats and guinea pig intestinal in vitro, DHE excited intestinal smooth muscle concentration in order 10 ~ 100, 0.1 ~ 10 and 10 ~ 100μmol·L-1, respectively. The concentrations of morphine stimulated intestinal smooth muscle were 0.1 ~ 10,0.002 ~ 2.0 and 0.1 ~ 10μmol·L-1 , While DHE is excited at concentrations of intestinal smooth muscle that are unobtainable in vivo at analgesic doses. Conclusions: DHE is different from morphine in intestinal smooth muscle. DHE shows a relaxation effect, while morphine has a contractile effect.