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[目的]观察奥美拉唑联合自拟黄芪和中汤加味治疗十二指肠球部溃疡(DU)并幽门螺杆菌(Hp)阳性患者的临床疗效。[方法]将126例经胃镜或钡餐检查诊断为DU患者随机分为2组,对照组以西医三联治疗方案治疗,治疗组以口服奥美拉唑配合黄芪和中汤加味治疗,4周为1个疗程。4周后做胃镜复查并做快速尿素酶试验检测Hp。[结果]治疗组疗效及Hp转阴率均明显高于对照组(均P<0.05),复发率明显低于对照组(P<0.05)。[结论]奥美拉唑联合自拟黄芪和中汤加味治疗DU具有疗效高、Hp转阴率高的优势,且无明显不良反应、复发率又低,值得推广应用。
[Objective] To observe the clinical efficacy of omeprazole combined with self-made Astragalus and Zhong Tang decoction in the treatment of patients with duodenal ulcer (DU) and positive H. pylori (Hp). [Method] A total of 126 patients diagnosed with DU by endoscopy or barium meal examination were randomly divided into two groups. The control group was treated with western medicine and triple therapy. The treatment group was orally treated with omeprazole plus Astragalus and Zhong Tang, A course of treatment. 4 weeks after gastroscopy review and rapid urease test to detect Hp. [Results] The curative effect and the negative conversion rate of Hp in the treatment group were significantly higher than those in the control group (all P <0.05). The relapse rate was significantly lower than that in the control group (P <0.05). [Conclusion] Combination of omeprazole and self-made Astragalus and Zhong Tang decoction in the treatment of DU has the advantages of high curative effect and high Hp negative conversion rate, with no obvious adverse reactions and low recurrence rate, which deserved to be popularized and applied.