采用腹腔内置管灌注大剂量抗癌药物治疗28例,手术不能切除和姑息切除术后广泛转移的晚期消化道癌肿,总有效率53.50%,75.60%患者经2～3次化疗后腹胀、腹痛等临床症状改善;4～6 次化疗后腹水明显减少,癌性发热得到控制,具有肯定的疗效,这种化疗方法,可延长晚期消化道恶性肿瘤的生存期,是一种安全可靠、毒副作用小,患者痛苦少的较好治疗方法,在临床中有推广应用价值. 28 cases of high-dose anticancer drugs were intraperitoneally infused into the peritoneal cavity. The advanced gastrointestinal cancers that could not be removed after surgery and palliative resection were treated with a total effective rate of 53.50%. 75.60% of the patients suffered abdominal distension and abdominal pain after 2 to 3 cycles of chemotherapy. Other clinical symptoms improved; 4 to 6 times of chemotherapy reduced ascites, and cancerous fever was controlled, with a positive effect. This chemotherapy can prolong the survival of advanced gastrointestinal cancer, which is a safe, reliable and toxic side effect. Small, less painful patients with better treatment, in the clinical application value.