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黄芫花醇提物羊膜腔、宫腔给药对中期妊娠家兔引产有效;灌胃、阴道给药无效;静脉给药毒副反应明显,引产作用不确实。小鼠腹腔给药LD_(60)为3.0g/kg,95％可信限为2.8～3.2g/kg。有局部刺激性、致热反应及溶血作用,无抗原性。在一定的剂量范围内可加强大鼠离体子宫肌的收缩;家兔子宫排空完全,引出胎子为死胎。病理检查胎盘蜕膜细胞、绒毛膜滋养层细胞变性坏死。分离筛选得芫花酯甲为其有效单体之一。
Astragalus alcohol extract amniotic cavity, intrauterine administration was effective in the induction of labor in mid-pregnancy rabbits; intragastric administration and vaginal administration were ineffective; intravenous administration of toxic side effects was obvious, and induction of labor was inaccurate. The dose of LD_(60) was 3.0 g/kg intraperitoneally in mice, with a 95% confidence limit of 2.8 to 3.2 g/kg. Local irritation, pyrogenic reaction and hemolysis, no antigenicity. In a certain dose range, the contraction of rat uterine muscles can be enhanced; the house rabbit is emptying completely and the fetus is extracted as stillbirth. Pathological examination of placental decidual cells, chorionic trophoblast cells degeneration and necrosis. Separation and selection of Alum-A as one of its effective monomers.