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目的:观察高三尖杉酯碱(HHT)、阿糖胞苷(Ara-C)、阿克拉霉素(Acla)三药联合(HAA)方案对老年初发急性髓系白血病(AML)的疗效。方法:老年初发AML患者20例,以HAA方案进行诱导化疗,观察其有效率和不良反应。结果:20例老年AML患者中完全缓解(CR)14例(占70%),其中一疗程CR 12例(占60%),部分缓解(PR)2例(占10%),总有效率达80%。结论:HAA方案可以作为一般状况良好的初治老年AML患者的有效治疗方案,其不良反应可以耐受。
OBJECTIVE: To observe the effect of HHT, Ara-C and Acla combined with trimethoprim (HAA) on acute primary myeloid leukemia (AML) in elderly patients. Methods: Twenty new-onset AML patients were induced by chemotherapy with HAA regimen. The effective rate and adverse reactions were observed. Results: In 20 elderly patients with AML, complete remission (CR) occurred in 14 patients (70%). One course of treatment was CR 12 (60%) and partial remission (PR 2) (10%). The total effective rate 80%. Conclusion: The HAA regimen can be used as an effective treatment regimen for elderly untreated AML patients with good general condition, and its adverse reactions can be tolerated.