近年来研究发现 ,人类部分结直肠癌与其他癌种基因组有微卫星不稳定 ( MSI)现象。导致 MSI的原因是 DNA错配修复机制缺损。 MSI最初是在遗传性非息肉性结直肠癌 ( HNPCC)中发现的 ,现在大量资料证实 ,检测 MSI有助于筛查 HNPCC早期患者。但目前用于检测结直肠癌 MSI的方法和评 Recent studies have found that human colorectal cancer and other cancerous genomes have microsatellite instability (MSI). The cause of MSI is a defective DNA mismatch repair mechanism. MSI was originally found in hereditary non-polyposis colorectal cancer (HNPCC), and a large amount of data now confirms that detection of MSI can help screen early HNPCC patients. However, the methods and evaluations currently used for the detection of colorectal cancer MSI