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目的探讨应用液基薄层制片技术将子宫内膜刷所采集到的子宫内膜细胞进行细胞学检测并联合宫腔镜检查,筛查子宫内膜病变的可行性及临床价值。方法 2012年7月至2012年12月河北省人民医院收治的因高危因素或有临床症状的500例患者,同时行子宫内膜细胞学检查和分段诊刮术,对比两种方法的取材满意率及诊断结果,对诊刮不满意的患者同时行细胞学和宫腔镜检测,并送病理,比较两种方法的诊断准确率。结果子宫内膜取样器法取材满意率为98%,诊断性刮宫术取材满意率为89%,两者取材满意率相比差异有统计学意义(P<0.05)。子宫内膜细胞学检测和宫腔镜检测在诊断结果符合率方面无统计学意义(P>0.05)。结论子宫内膜刷采集子宫内膜细胞并结合液基薄层技术进行制片,对分段诊刮不满意的细胞学可疑阳性患者进行宫腔镜的进一步检测,在筛查子宫内膜癌及其癌前病变方面是完全可行的。
Objective To investigate the feasibility and clinical value of using liquid-based lamellar technique to detect endometrial cells collected by endometrial brush in combination with hysteroscopy to screen for endometrial lesions. Methods From July 2012 to December 2012, 500 patients with high risk factors or clinical symptoms admitted to Hebei Provincial People’s Hospital were enrolled in this study. Endometrial cytology and sectional curettage were performed at the same time. Rate and diagnostic results, the doctor is not satisfied with the curettage simultaneously cytology and hysteroscopy, and sent to the pathology, the diagnostic accuracy of the two methods. Results The satisfactory rate of endometrial sampler was 98%, and that of diagnostic curettage was 89%. There was significant difference (P <0.05) between the two methods. Endometrial cytology and hysteroscopy in the diagnosis of the coincidence rate was not statistically significant (P> 0.05). Conclusion The endometrial brush cells collected endometrial cells combined with liquid-based thin-layer technology for film production, the dissatisfied segmented curettage positive cytology suspicious patients for further detection of hysteroscopy in screening endometrial cancer and Its precancerous lesions are completely feasible.