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目的:探讨乙肝罕见模式产生原因及临床意义。方法:随机抽取18例罕见模式45例常见模式患者,检测其HBV DNA及肝功能。结果:前者HBV DNA>1×105IU/ml者占93.2%,均值4.58×105IU/ml,肝功指标总异常率64.2%;后者HBV DNA>1×105IU/ml者占100%,均值6.21×106IU/ml,肝功指标总异常率59.3%。两组HBV DNA定量、肝功指标总异常率差异均无统计学意义(P>0.05)。结论:罕见模式的出现并非是乙肝好转或恢复,其病毒仍在复制肝功仍有受损。
Objective: To explore the causes and clinical significance of the rare mode of hepatitis B Methods: A total of 18 cases of rare pattern of 45 common patterns of patients were randomly selected to detect HBV DNA and liver function. Results: The former accounted for 93.2% of patients with HBV DNA> 1 × 105 IU / ml, with a mean of 4.58 × 105 IU / ml and a total abnormal rate of liver function indicators of 64.2%; the latter accounted for 100% of HBV DNA> 1 × 105 IU / ml with a mean of 6.21 × 106IU / ml, total abnormal liver function indicators 59.3%. There was no significant difference between the two groups in the quantification of HBV DNA and the total abnormal rate of liver function (P> 0.05). CONCLUSIONS: The rare pattern of emergence is not the improvement or recovery of hepatitis B, but the virus is still impaired in the replication of liver function.