论文部分内容阅读
目的探讨利多卡因用于联合坐骨神经-“三合一”阻滞的临床药效学和药代动力学特性。方法rrrrrrrrn20 例择期行下肢手术的患者，随机分为盐酸利多卡因组和碳酸利多卡因组，每组10 例。均采用联合坐骨神经-“三rrrrrrrrn合一”阻滞，分别使用600m g 含肾上腺素的盐酸利多卡因和碳酸利多卡因。首先行坐骨神经阻滞，随后行“三合一”阻rrrrrrrrn滞。在第2 次注药后的5 、10 、20 、30 、40 、50 、60 及90m in 采静脉血测定血药浓度，并对感觉和运动阻滞进行评价。结rrrrrrrrn果两组血浆利多卡因浓度均在安全范围内，无一例患者出现临床毒性反应。碳酸组麻醉完善时间明显快于盐酸组，且血浆药物浓度达峰值时间（Tm ax）提前，而两组麻醉维持时间、血药峰值浓度（Cm ax）、血药-时曲线下面积（AUC）比rrrrrrrrn较均无显著性差异。结论含肾上腺素的碱化利多卡因可明显缩短麻醉完善时间，而血浆药物浓度未明显增加。
Objective To investigate the clinical pharmacodynamic and pharmacokinetic properties of lidocaine combined with sciatic nerve in the “triplex” block. Methods Twenty patients undergoing elective surgery for lower extremity were randomly divided into lidocaine hydrochloride group and lidocaine carbonate group, with 10 patients in each group. All use the combined sciatic nerve - “triple” block, respectively, with 600m g of adrenaline containing lidocaine hydrochloride and lidocaine carbonate. The first line of sciatic nerve block, followed by “three in one” resistance r r r r r r r n hysteresis. Blood concentrations were measured at 5, 10, 20, 30, 40, 50, 60 and 90 mins after the second injection and the sensory and motor block were evaluated. Results Plasma concentrations of lidocaine in both groups were within safe limits, and none of the patients had clinical toxicities. The time to complete anesthesia in carbonic acid group was significantly faster than that in hydrochloric acid group, and the peak plasma drug concentration (Tm ax) was earlier, while the anesthetic maintenance time, peak blood concentration (Cm ax), area under the curve of plasma drug- No significant difference compared with r r r r r r r r n. Conclusion Adrenaline alkalized lidocaine can significantly shorten the anesthesia time, while the plasma drug concentration did not increase significantly.