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A、B 和H 血型抗原与胃肠道肿瘤的关系早巳为人们所熟知。一般而言,癌变时组织丧失固有的A、B 和H 血型抗原,此外,A 样的血型抗原尚可见于B 型或O 型的个体肿瘤组织中。Lewis 血型物质与胃肠道肿瘤抗原的关系却是新近提出的课题,Koprowski 等采用单克隆抗体对此进行了深入的研究。本文拟介绍这方面的主要内容,并对与肿瘤抗原研究相关的一些问题进行讨论。通常将Lewis 血型的发现归功于Mou-rant,他在1946年发现两位产妇的血清中含有Le~(?)抗体,致使其婴儿患新生儿溶血。1948年
The relationship between A, B and H blood group antigens and gastrointestinal tumors has long been known. In general, cancerous tissue loses intrinsic A, B, and H blood group antigens. In addition, A-like blood group antigens are found in individual tumor tissues of type B or O. The relationship between Lewis blood group substances and gastrointestinal tumor antigens is a newly proposed subject, and Koprowski et al. Conducted an in-depth study using monoclonal antibodies. This article is intended to introduce the main contents of this area, and discuss some issues related to tumor antigen research. The discovery of the Lewis blood type is usually attributed to Mou-rant, who in 1946 found that the two maternal sera contained Le antibody, causing infants to have newborn hemolysis. 1948