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目的研究骨密度和血清中骨代谢指标水平与患者骨质疏松骨折的临床关系。方法选择2014年9月-2016年9月在本院健康体检的70例老年人群作为研究对象,采用骨密度仪进行骨密度检测,所有患者均抽血检测患者骨代谢相关指标;根据随访期间患者是否发生骨质疏松性骨折,分为发生骨质疏松骨折的观察组(17例)和未发生骨质疏松骨折的对照组(53例),对比2组骨密度和骨代谢相关指标,采用Logistics回归模型探讨影响骨质疏松患者骨折的风险因素。结果观察组患者腰椎、股骨颈、股骨粗隆、Ward三角区骨密度均低于对照组患者,观察组患者甲状旁腺激素(PTH)、钙(Ca)、活性维生素D3[25(OH)D3]水平均低于对照组患者,差异有统计学意义(P<0.05);而磷(P)水平高于对照组患者,差异有统计学意义(P<0.05);Logistic回归分析果提示PTH、维生素D3、股骨颈骨密度是骨质疏松骨折的独立风险因素(P<0.05)。结论骨代谢指标和骨密度是骨质疏松骨折的独立风险因素。
Objective To study the clinical relationship between bone mineral density (BMD), serum bone metabolism index and osteoporotic fracture in patients. Methods Seventy elderly people in our hospital from September 2014 to September 2016 were enrolled in this study. Bone densitometry was used to measure the bone mineral density (BMD). All the patients were drawn blood to detect the bone metabolism related indexes. According to the patients’ Osteoporotic fractures were divided into observation group (17 cases) with osteoporosis fracture and control group (53 cases) without osteoporosis fracture. Bone mineral density and bone metabolism related indexes were compared between two groups. Logistics Regression model to explore the risk factors of fractures in patients with osteoporosis. Results The BMD of lumbar spine, femoral neck, femur trochanter and Ward triangle in the observation group were lower than those in the control group. The levels of PTH, Ca and active vitamin D3 [25 (OH) D3 (P <0.05). However, the level of P (P) was higher in the control group than in the control group (P <0.05). Logistic regression analysis showed that PTH, Vitamin D3 and femoral neck BMD were independent risk factors of osteoporotic fracture (P <0.05). Conclusion Bone metabolism and bone mineral density are independent risk factors for osteoporotic fractures.