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四预防接种用生物制品之保管预防接种用生物制品,一般应保存在2-10℃的温度下,在使用时也应当在阴凉的室内。不宜在旷场上被日光曝晒。冰冻会使生物制品免疫效价降低,对流行性乙型脑炎疫苗等制品,冰冻后鼠脑组织冻成块状,无法抽取注入人体。稀释的血清,冰冻后血清中蛋白质和防腐剂的浓度增高,而后者的升高,会造成血清的破坏。高温也会使疫苗降低免疫力以至失效。牛痘苗在室温下一周内就会失效,卡介苗、流行性乙型脑炎疫苗不能在室温内曝露30分钟以上,通常规定为5分钟,因此上记疫苗在运输途中亦应保持在0—10℃的温度下。在2—10℃的温度下,浓缩的免疫血清每年破坏速度不超过3%,普通的免疫血清不超过10%;但在37℃时,前者每年破坏10—20%;后者每年可破坏25—50%。
Preservation of four vaccination biological products Vaccination biological products should generally be stored at 2-10 ℃ temperature, should also be used in a cool indoor. Should not be exposed to sunlight in the open field. Frozen immune bio-products will reduce the potency of the Japanese encephalitis vaccine and other products, frozen rat brain tissue frozen into lumps, can not be extracted into the body. Diluted serum, frozen serum protein and preservative concentrations increased, while the latter increased, will cause the destruction of serum. High temperatures can also reduce the vaccine immunity and even failure. Vaccinia vaccine will fail within a week at room temperature. Bacille Calmette-Guerin, JE vaccine should not be exposed for more than 30 minutes at room temperature, usually for 5 minutes. Therefore, the above vaccines should also be kept at 0-10 ° C during transport Of the temperature. At 2-10 ° C, the concentrated immune serum destroys not more than 3% per annum and less than 10% for normal immune sera, whereas the former destroys 10-20% per annum at 37 ° C; the latter destroys 25% -50%.