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涤痰散由胆星、建曲、巴豆等组成,治疗58例哮喘患儿,临床总有效率89.7%。用卵蛋白致敏和激发大鼠,造成哮喘模型,测定其气道阻力(R)、肺顺应性(C)、血嗜酸细胞(EC)数。结果:模型组动物较正常对照组 R 显著增大(P<0.01)、C 显著降低(P<0.05)、EC 显著增加(P<0.01)。涤痰散治疗组较模型组 R 显著降低(P<0.01),C 显著升高(P<0.01),EC 显著减少(P<0.01)。提示涤痰散具有抑制血 EC 增多、改善哮喘发作时动物气道狭窄等病理改变的作用。
Ditan scattered by the gallbladder, built song, Croton and other components, the treatment of 58 cases of asthma in children, the total effective rate of 89.7%. Rats were sensitized and challenged with ovalbumin, resulting in an asthma model. The airway resistance (R), lung compliance (C), and blood eosinophil (EC) numbers were determined. Results: Compared with normal control group, R of model group increased significantly (P <0.01), C significantly decreased (P <0.05), EC increased significantly (P <0.01). Ditan decoction treatment group was significantly lower than the model group R (P <0.01), C was significantly increased (P <0.01), EC was significantly reduced (P <0.01). Tip Ditan scattered have inhibited the increase of blood EC, asthma attack to improve animal airway stenosis and other pathological changes.