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目的：对比腹腔镜经胆囊管胆道探查术（ laparoscopic trans-cystic bile duct explora-tion，LTCBDE）与腹腔镜胆总管探查一期缝合术（laparoscopic common bile duct exploration and prima-ry suture，LBEPS）治疗胆囊结石继发胆总管结石的疗效，分析两种手术方式在临床上的应用价值。方法胆囊结石合并胆总管结石患者157例，依据手术方式不同，将其分为 LTCBDE 组（95例）和LBEPS 组（62例），比较两组患者手术时间、住院时间、住院总费用及术后并发症（胆漏、胆道感染、切口感染）等临床指标。结果 LTCBDE 组术后住院时间[（11.1±3.3）d vs（13.7±4.6）d]、住院总费用[（3.0±0.4）万元 vs（3.2±0.3）万元]均低于 LBEPS 组，差异有统计学意义（P 0.05）。结论 LTCBDE 是一种安全、有效、可行的手术方式，可作为治疗胆囊结石继发胆总管结石的一种优先选择方案之一。“,”Objective Comparative study on clinical efficacy and outcomes between laparoscopic trans-cystic bile duct exploration(LTCBDE)and laparoscopic trans-cystic bile duct exploration(LBEPS) in the treatment of cholecystolithiasis and secondary choledocholithiasis. Methods A retrospective analy-sis of a total 157 cases with both cholecystolithiasis and choledocholithiasis. According to different surgical methods,they were divided into two groups:LTCBDE group(n = 95)and LBEPS group(n = 62). Compara-tive analysis of patients operation duration,intra operative blood loss,hospital stay,total hospital cost and post operative complications(bile leakage,biliary tract infection,wound infection,etc. )of the two groups. Results The group LTCBDE′s operative hospital stay[(11. 1 ± 3. 3)d vs(13. 7 ± 4. 6)d]& total hospi-tal cost[(30 ± 4)thousand vs(32 ± 3)thousand]were lower than group LBEPS,the difference was statis-tically significant(P 0. 05). Conclusion LTCBDE is a safe,effective and feasible surgical method which has certain advantages in comparison to LBEPS group. LTCBDE can be considered as the first choice in the treatment of cholecystolithiasis and secondary choledocholithiasis.