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控制给药不仅意味延长药物的作用时间,并且包括药物释放动力学的预测和重现。口服控释给药考虑三方面内容: 1.给药系统:开发一种可行的给药系统,使药物最适宜于治疗,以预定的速率释放,达到要求的作用时间。 2.通过胃肠的时间:延长胃肠的驻留时间,使给药系统在吸收部位滞留足够的时间,以运送负荷的全部药物。 3.肝脏“首过”消除:如药物具有较大的肝“首过”效应,必须有预防措施以减轻其程度。
Controlled dosing not only means prolonging the duration of action of a drug, but also includes predicting and reproducing the drug release kinetics. Oral controlled release drug administration Consider three aspects: 1. Drug Delivery System: Develop a viable drug delivery system that will make the drug most suitable for treatment and release at a predetermined rate to achieve the desired duration of action. 2. Through the gastrointestinal time: to extend the residence time of the gastrointestinal, the delivery system in the absorption part of the retention time enough to carry the load of the entire drug. 3. Liver “first pass” to eliminate: If the drug has a larger liver “first pass” effect, there must be preventive measures to reduce its extent.