Background:Gastric stromal tumors arising from the muscularis propria are located in deeper layers.Endoscopic resection may be contraindicated due to the possibility of perforation.These tumors are therefore usually removed by surgical or laparoscopic procedures.This study evaluated the curative effects,safety and feasibility of endoscopic full-thickness resection (EFR) of gastric stromal tumors originating from the muscularis propria.Methods:This study enrolled 92 patients with gastric stromal tumors ＞2.5 cm originating from the muscularis propria.Fifty patients underwent EFR,and 42 underwent laparoscopic intragastric surgery.Operation time,complete resection rate,length of hospital stay,incidence of complications,and recurrence rates were compared in these two groups.Results:EFR resulted in complete resection of all 50 gastric stromal tumors,with a mean procedure time of 85 ± 20 min,a mean hospitalization time of 7.0 ± 1.5 days and no complications.Laparoscopic intragastric surgery also resulted in a 100％ complete resection rate,with a mean operation time of 88 ± 12 min and a mean hospitalization period of 7.5 ± 1.6 days.The two groups did not differ significantly in operation time,complete resection rates,hospital stay or incidence of complications (P ＞ 0.05).No patient in either group experienced tumor recurrence.Conclusions:EFR technique is effective and safe for the resection of gastric stromal tumors arising from the muscularis propria.