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采用含关木通复方及拆方短期给药方法 ,观察小鼠给药前后体重、血尿生化及肾组织学变化 ,目的是判断关木通及其复方是否有肾毒性 ,为临床安全用药提供实验依据。1 材料与方法1.1 实验动物和材料昆明小鼠 180只 ,♀♂各半 ,3月龄 ,体重 (2 5±2 ) ｇ ,随机分 9组 :①对照组 (
The short-term administration method of Guan Mu Tong Fu Fang and decontamination was used to observe the body weight, hematuria, and renal histological changes before and after administration in mice. The purpose was to determine whether Guan Mu Tong and its compound had nephrotoxicity and provide experimental basis for clinical safe drug use. 1 Materials and methods 1.1 Experimental animals and materials 180 Kunming mice were divided into 3 groups, 3 months old, weight (2 5±2) g, randomly divided into 9 groups: 1 control group (