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1例出生3 d的新生儿因感染性黄疸给予头孢吡肟0.16 g溶于5%葡萄糖注射液20 ml静脉滴注、1次/12 h。第6天，患儿左外眼角、颈部皮肤发红，双腋下皮肤发红、糜烂、表皮大片脱落，皮肤脱落面积大约为2.0 cm×2.5 cm。考虑为头孢吡肟引起的剥脱性皮炎，停用该药，给予小檗碱药浴、红霉素软膏外用。3 d后患儿皮肤糜烂明显好转，无新发皮肤剥脱，黄疸明显消退。1个月后随访，患儿黄疸完全消退，皮损已痊愈。“,”A 3-day-old newborn received an IV infusion of cefepime 0.16 g dissolved in 5% glucose injection 100 ml once per 12 hours for infectious jaundice. On the 6th day, the infant developed skin redness on the left lateral canthus, neck, and armpits. Erosion and large pieces of epidermal detachment occurred on the armpit skin. The area of skin exfoliation was about 2 cm×2.5 cm. It was considered to be exfoliative dermatitis induced by cefepime. Cefepime was discontinued, berberine was dissolved in water for bathing, and erythromycin ointment was used externally. Three days later, the skin erosions improved markedly, no new skin exfoliation occurred, jaundice subsided obviously. At 1 month of follow-up, the jaundice completely disappeared and the skin lesion healed.