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内皮抑素 (endostatin)是近年来发现的 ,天然产生的新血管生成抑制因子。它在体内由胶原ⅩⅧ经酶解产生 ,可以抑制新血管生成 ,在肿瘤动物模型中显示出显著的抑瘤活动。通过抑制肿瘤相关的新血管的形成来治疗肿瘤 ,是目前出现的新疗法 ,内皮抑素是这种疗法中很有前景的侯选药物之一。在美国已经开始了用内皮抑素治疗肿瘤的Ⅰ期临床试验 ,关于它的临床前基础实验也在广泛开展。本文综述了内皮抑素在肿瘤治疗中的应用基础研究
Endostatin is a naturally occurring neovascularization inhibitor found in recent years. It is enzymatically produced in vivo by collagen XVIII, which inhibits neovascularization and shows significant antitumor activity in tumor animal models. The treatment of tumors by inhibiting the formation of neovascular neoplasms is a new therapy presently emerging and endostatin is one of the promising drug candidates for this therapy. A phase I clinical trial of endostatin-treated tumors in the United States has started, and preclinical basic experiments are also underway. This article reviews the basic research of endostatin in the treatment of cancer