报告环孢素A在6例尸体肾移植中的应用。其中有5例肾功能正常,人、肾存活率达83.3%。1例术后发生3次排斥反应,后死于高血压继发的脑出血,死亡率为16.7%。存活5例中有1例术后5个半月因C_sA减量太快和停用,发生不典型排斥反应后复用C_sA,按每日4～7mg/kg,一月后C_r逐渐下降为265.2～362.4μmol/L,现已14个月,一般情况好。1例患者术前2月曾患黄疸性肝炎,和1例动静脉外瘘处感染未愈,经用以CsA为主的免疫抑制剂后,未发生任何并发症,恢复良好。文中并阐明了延迟应用C_sA的优越性和出现C_sA中毒的临床处理方法。 Report of cyclosporin A in 6 cases of cadaver kidney transplantation. Among them, 5 cases of normal renal function, human, kidney survival rate of 83.3%. One case had 3 rejection after operation and died of cerebral hemorrhage secondary to hypertension with a mortality rate of 16.7%. Survival in 5 cases, 1 case of 5 and a half months after C_sA reduction too fast and disabled, recurrence of atypical rejection response C_sA, daily 4 ~ 7mg / kg, C_r after January gradually decreased to 265.2 ~ 362.4μmol / L, now 14 months, the general situation is good. One patient had jaundice hepatitis at 2 months before operation and one case of arteriovenous fistula infection did not heal. After CsA-based immunosuppressive agents were used, no complications occurred and recovery was good. The article also illustrates the advantages of delayed application of C_sA and the clinical treatment of C_sA poisoning.