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目的探讨鼻疗法喷剂对硝酸甘油所致偏头痛大鼠模型行为症状的影响。方法60只大鼠分为6组:空白、模型、阳性药、大、中、小剂量组,应用硝酸甘油制作实验性偏头痛大鼠模型,造模后30 min,空白、模型组灌胃生理盐水,阳性药组灌胃天舒胶囊溶液,大、中、小剂量组分别滴以不同剂量的鼻疗法喷剂,采用时间分段计数法持续观察给药后大鼠行为症状变化。结果治疗组行为症状显著好于模型组。结论鼻疗法喷雾剂对硝酸甘油所致实验性偏头痛大鼠模型行为学症状有较明显的缓解作用。
Objective To investigate the effect of nasal spray on behavioral symptoms of migraine rat model induced by nitroglycerin. Methods 60 rats were divided into 6 groups: blank, model, positive drug, large, middle and small dose group. Experimental migraine rat model was made by using nitroglycerin. At 30 min after model establishment, Saline, positive drug group Tianshu capsule gavage solution, large, medium and small dose groups were treated with different doses of nasal spray, the use of time-counting method to observe the change of behavioral symptoms in rats after administration. Results The behavioral symptoms in the treatment group were significantly better than those in the model group. Conclusion Nasal therapy sprays have obvious relieving effect on behavioral symptoms of experimental migraine rats caused by nitroglycerin.