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目的:探讨转化生长因子β_1(TGFβ_1)、血清酸性同功铁蛋白(SAIF)、异常凝血酶原(DCP)、γ-谷氨酰转肽酶同功酶γ-GTⅡ等肝癌标志物联合检测对原发性肝癌(PHC)的诊断价值。方法:选择43例 PHC(22例组织学证实)和77例其他肝病及消化道恶性肿瘤患者进行肝癌标志物的同步测定。结果:PHC 的TGFβ_1、SAW、DCP、γ-GTⅡ较正常对照组显著增高(P 值<0.01),PHC 组各项标志物的敏感性依次为γ-GTⅡ(81.%%)>SAIF(74.4%)>TGFβ_1(72.3%)>DCP(62.8%),特异性依次为γ-GTⅡ和 DCP(89.6%)>SAIF(81.8%)>TGFβ_1(77.9%),结合 AFP 联合检测的阳性率达95.5%。同时可将 AFP 阴性 PHC 及小肝癌的诊断阳性率提高到85.7%。结论:肝癌标志物联合检测对诊断 PHC 有重要价值,尤其是 AFP 阴性 PHC及小肝癌的诊断阳性率得到提高。
Objective: To investigate the combined detection of TGFβ1, SAIF, DCP, γ-glutamyl transpeptidase isoenzyme γ-GTII and other liver cancer markers. The diagnostic value of primary liver cancer (PHC). METHODS: Simultaneous determination of liver cancer markers was performed in 43 cases of PHC (22 cases confirmed histologically) and 77 cases of other liver and digestive tract malignancies. Results: The levels of TGFβ_1, SAW, DCP, γ-GTII in PHC were significantly higher than those in normal control group (P<0.01). The sensitivity of each marker in PHC group was γ-GTII(81.%%)>SAIF(74.4). %)> TGFβ_1 (72.3%)> DCP (62.8%), specificity was γ-GTII and DCP (89.6%)> SAIF (81.8%)> TGFβ_1 (77.9%). The positive rate of combined detection of AFP was 95.5. %. At the same time, the diagnostic positive rate of AFP negative PHC and small hepatocellular carcinoma can be increased to 85.7%. Conclusion: Combined detection of hepatocellular carcinoma markers is of great value in diagnosing PHC, especially the positive rate of AFP negative PHC and small hepatocellular carcinoma.